Matricellular proteins in cancer: a focus on secreted Frizzled-related proteins
نویسندگان
چکیده
منابع مشابه
Secreted frizzled related proteins: Implications in cancers.
The Wnt (wingless-type) signaling pathway plays an important role in embryonic development, tissue homeostasis, and tumor progression becaluse of its effect on cell proliferation, migration, and differentiation. Secreted frizzled-related proteins (SFRPs) are extracellular inhibitors of Wnt signaling that act by binding directly to Wnt ligands or to Frizzled receptors. In recent years, aberrant ...
متن کاملSecreted Frizzled-related proteins can regulate metanephric development
Wnt-4 signaling plays a critical role in kidney development and is associated with the epithelial conversion of the metanephric mesenchyme. Furthermore, secreted Frizzled-related proteins (sFRPs) that can bind Wnts are normally expressed in the developing metanephros, and function in other systems as modulators of Wnt signaling. sfrp-1 is distributed throughout the medullary and cortical stroma...
متن کاملA pan-cancer analysis of secreted Frizzled-related proteins: re-examining their proposed tumour suppressive function
Secreted frizzled-related proteins (SFRPs), containing five family members (SFRPs 1-5) are putative extracellular Wnt inhibitors. Given their abilities to inhibit Wnt signalling, as well as the loss of SFRP1 in many cancers, this family is generally considered to be tumour suppressive. In this study we analyzed gene expression, promoter methylation and survival data from over 8000 tumour and no...
متن کاملSecreted frizzled related proteins inhibit fibrosis in vitro but appear redundant in vivo
BACKGROUND The pathogenesis of pulmonary fibrosis remains poorly understood. The Wnt signaling pathway regulates fibrogenesis in different organs. Here, we studied the role of two extracellular Wnt antagonists, secreted frizzled-related protein-1 (SFRP1) and frizzled-related protein (FRZB) on lung fibrosis in vitro and in vivo. For this purpose, we used an alveolar epithelial cell line and a lu...
متن کاملHypermethylation of secreted frizzled-related proteins predicts poor prognosis in non-M3 acute myeloid leukemia
OBJECTIVE Secreted frizzled-related proteins (SFRPs) as Wnt signaling antagonists have been found to be dysregulated by promoter hypermethylation in several cancers including acute myeloid leukemia (AML). This study aimed to investigate the methylated status of SFRPs promoter region and its clinical relevance in Chinese non-M3 AML patients. METHODS SFRPs methylation in 139 primary non-M3 AML ...
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ژورنال
عنوان ژورنال: Journal of Cell Communication and Signaling
سال: 2017
ISSN: 1873-9601,1873-961X
DOI: 10.1007/s12079-017-0398-2